Oral hypoglycaemic drugs and newer agents used in type 2 diabetes mellitus

P Joshi, S Joshi

Abstract


This article reviews the use of oral agents in the management of type 2 diabetes, together with their pharmacological mechanisms, indications, side effects and contra-indications. The principal oral agents available for use include metformin, sulphonylureas, non-sulphonylurea secretagogues (meglitinides), thiazolidinediones, and alpha-glucosidase inhibitors. More recently, DPP-IV Inhibitors and Glucagon-like peptide-1 agents have been registered for use in the United States and in Europe. They await Medicines Control Council registration for use in South Africa.

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SA Fam Pract | ISSN: 1726-426X

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